In 2000 they return to Buenos Aires and begin together their independent practice, building several residential and commercial projects. In 2004 they won their first major architectural competition, a 100,000 sq.ft.-addition to the University of Buenos Aires School of Economics, currently under construction. In 2006 they won their second national design competition, for a new 450,000 sq.ft.-building for the UBA School of Psychology. They were also awarded second prize in the República Square redesign competition (Buenos Aires, 2001), second prize in the Instituto Técnico Judicial competition (Buenos Aires, 2009) and mentions in the Fiscalías Competition (Madrid, Spain, 2006), the Jeongok Prehistory Museum competition (Gyeonggi-do Jeongok, South Korea, 2006) and the Santa Fe Courthouse Addition Competition (Santa Fe, Argentina, 2005).

They have recently been selected by Jacques Herzog, from swiss firm Herzog & de Meuron, to be one of the 100 firms participating in the Ordos 100 project in China, Each invited firm will design a 10,000 sq.ft. villa on a master plan by chinese arqchitect Ai Weiwei. They have also been invited by Yansong Ma, from Beijing-based firm i-MAD, to design one of the buildings of the Guiyang Hua Xi Urban Center, in the Chinese province of Guizhou.

They have been part of several exhibitions and events such as the XVI Bienal de Arquitectura de Santiago, Chile, the first Bienal de Arquitectura Latinoamericana in Pamplona, Spain, Pecha Kucha Nights and Inspiration Fest at Centro Cultural Konex in Buenos Aires. Their work has been published in numerous magazines such as A+U, 2G, Arquitectura Viva, Arquine, Monument, Frame, Metropolis and Wallpaper.

They are at present design studio professors in the University of Buenos Aires School of Architecture, Design and Urbanism. Tristan Dieguez is also assistant professor at Washington University in St. Louis, USA.